The fabrication of nanoscale solid lipid particles involved a wide variety of techniques such as, high pressure homogenization, microemulsion, solvent emulsification, double emulsion and solvent injection method with various degrees of quality, time, and expense.
Nanopharmaceutical have provided an effective way to overcome this difficulty and used to minimize the drug degradation upon administration, enhance the bioavailability and in vivo efficiency of many drugs, increase the specificity towards the cell, improved the stability of sensitive agents, increase the target efficiency and to control the release of drug. Delivery of RM into brain is huge challenge because of unique property of blood brain barrier. RM is a novel irreversible monoamine oxidase type B-inhibitor, secondary cyclic benzylamine and indane derivative of antiparkinson drug. Rasagiline (N-propargyl-1-R-aminoindan) mesylate (RM) is a second-generation of propargylamine used for the treatment of PD. Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of adult onset, after Alzheimer's disease and affecting 1-2% of general population. Nanopharmaceutical is a promising approach to deliver the drug into brain for neurodegenerative disorders. Through the development in nanotechnology, it may conceivably to fabricate the drug loaded nanoparticles that can be used in numerous novel applications. In pharmaceutical formulation development, 90% of the active ingredients exist in the form of solid particles. The term “nanopharmaceuticals” covers drug discovery, design, development and delivery of drug. The science and technology research in nanotechnology promises breakthroughs in the areas include manufacturing, medicine and healthcare, nanopharmaceuticals, biotechnology, nanoelectronics, information technology and National security. reported the development of nano based drug delivery expenditure was $3.4 billion in 2007 and approximately $26 billion in 2012 and in 2015 it is expected to be 220$. The London based largest nanotechnology consultancy company Cientifica Ltd. Over the past few decades, nanostructured materials have been fascinating and challenging the world of science and technology due to their amazing role in producing novel shapes, structures and the unusual phenomena associated with these materials. This study concludes that the AHP was viable and effective tool for selecting a most suitable method for the fabrication of RM loaded nanoscale solid lipid particles.
Drug content and entrapment efficiency of the RM-solid lipid nanoparticles were 97.26% and 86.57%, respectively.
Nanoscale solid lipid particles of RM was formulated by the selected microemulsion method (M4) and it shows the particle size, polydispersity index and zeta potential were within acceptable limits. The best alternative selected was based on the highest priority.
Ahp decision making softyware software#
After constructing the AHP, the expert choice software was used to compute the overall priority of criteria, sub-criteria and alternatives. In the AHP, a decision of hierarchy was constructed with a goal, criteria, sub-criteria, and alternatives. One of the possibilities to overcome these difficulties, AHP was employed to find the suitable method. Improper method selection may lead to waste of time, loss of material and financial resources. The objective of this study was to select best method for the development of rasagiline mesylate (RM) loaded nanoscale solid lipid particles using analytic hierarchy process (AHP).
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